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April 23, 2026International Journal of Analytical ChemistryOpen Access

Eco‐Conscious RP‐HPLC Method for Concurrent Quantification of Assay and Dissolution Testing of Methocarbamol and Diclofenac Potassium in Tablet Formulations

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Authors

HOHedia OuniYanbu University CollegeFAFahad M. AlminderejMSMostafa E. SalemImam Mohammad ibn Saud Islamic University

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Implication

This method quantifies methocarbamol and diclofenac potassium in tablets, indicating sustainable practices in pharmaceutical analysis.

Key Points

  • The aim is to develop a sustainable RP-HPLC method for simultaneous quantification of methocarbamol and diclofenac potassium in tablet formulations.
  • Developed a dual-function RP-HPLC method with a C8 column for chromatographic separation.
  • Conducted dissolution testing using USP Apparatus II at controlled temperature and pH.
  • Evaluated sustainability using Analytical Eco-Scale and other environmental indices.
  • Achieved low limits of detection and quantification for both active ingredients.
  • 75% of the drugs were released within 30 minutes during dissolution testing.
  • Method received high scores on eco-sustainability measures, validating its practicality for routine quality control.

Cite This Study

Ouni et al. (2026) studied this question.

synapsesocial.com/papers/69e9bb2285696592c86ecf91https://doi.org/10.1155/ianc/8947770
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