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October 13, 2025Archive of Ukrainian OphthalmologyOpen Access

Retinal plasminogen and plasmin content in experimental diabetic retinopathy and the effect of pharmacological blockade of cellular protein kinases

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Authors

KUK.O. UsenkoVMV.V. MykhailovskaСЗС. В. Зябліцев

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Overview

This study demonstrates the accumulation of plasminogen in diabetic retinopathy, highlighting insulin's effects and protein kinases' role.

Key Points

  • Experimental diabetic retinopathy showed a significant accumulation of plasminogen and plasmin in the retina.
  • Levels of plasmin increased significantly, with insulin and sorafenib reducing plasmin levels when combined.
  • Caspase-3 expression increased in ganglion cells with neurodegeneration, which was prevented by insulin and sorafenib.
  • The results suggest a promising potential for pharmacological modulation of protein kinases in retinal protection.

Cite This Study

Usenko et al. (2025) studied this question.

synapsesocial.com/papers/68ec51df42911f61ef8b219chttps://doi.org/10.22141/2309-8147.13.2.2025.413
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Also Consider

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