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September 5, 2025Medical Science of Ukraine (MSU)Open Access

Reactive Retinal Gliosis in Experimental Diabetic Retinopathy and the Effect of Inhibition of Cellular Protein Kinases

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Authors

KUK.O. Usenko

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Overview

Experimental study shows sorafenib reduces GFAP levels in retinal tissue of diabetic rats, suggesting therapeutic potential.

Key Points

  • Sorafenib prevented reactive gliosis in retinal tissues that developed diabetic retinopathy.
  • GFAP content in retinal tissues increased notably with diabetic retinopathy progression, highlighting gliosis.
  • Immunohistochemical analysis indicated that insulin treatment lowered GFAP expression compared to controls.
  • Results support the potential of sorafenib in treating early-stage diabetic retinal damage in experimental models.

Cite This Study

K.O. Usenko (2025) studied this question.

synapsesocial.com/papers/68bb49bc6d6d5674bccff683https://doi.org/10.32345/2664-4738.2.2025.05
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