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October 17, 2025Frontiers in EndocrinologyOpen Access

Growth factor and hypoxia-inducible factor alpha content in the retina of male Wistar rats in experimental diabetic retinopathy and the effect of cellular protein kinase blockade

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Authors

KUK.O. UsenkoOSOlena StrubchevskaSRS. О. Rykov

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Overview

Experimental study shows combined sorafenib and insulin significantly reduces VEGF and hif-1α in diabetic retinopathy, indicating potential treatment benefits.

Key Points

  • In diabetes-induced retinopathy, the VEGF content in the retina increased dramatically, highlighting its role in disease progression.
  • Administering insulin combined with sorafenib effectively blocked increases in VEGF and significantly reduced hif-1α expression to undetectable levels.
  • The combined treatment prevented both morphological changes and neurodegenerative effects in the retina associated with diabetic retinopathy.
  • Immunohistochemical analysis revealed degenerative changes in retinal structure due to localized increases in VEGF during diabetes.

Cite This Study

Usenko et al. (2025) studied this question.

synapsesocial.com/papers/68f199ccde32064e504dd0afhttps://doi.org/10.3389/fendo.2025.1643445
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1REACTIVE RETINAL GLIOSIS IN EXPERIMENTAL DIABETIC RETINOPATHY AND THE EFFECT OF INHIBITION OF CELLULAR PROTEIN KINASES2025
  2. 2Retinal plasminogen and plasmin content in experimental diabetic retinopathy and the effect of pharmacological blockade of cellular protein kinases2025
  3. 3Retinal glial activation in diabetic retinopathy: therapeutic impact of multikinase inhibition with sorafenib2025 · 4 citations
  4. 4Suppression of HIF-1α alleviates the symptoms associated with diabetic retinopathy in mice2025
  5. 5Role of IGF-1 Signaling in the Pathology of Diabetic Retinopathy2015 · 3 citations