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October 13, 2025Open Access

Blood Pressure Levels and the Progression of Chronic Kidney Disease: A Systematic Review

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Authors

ISIonata SmikadiGGG. GattoUniversity of MilanVPVítor Magno PereiraCentre Hospitalier Universitaire de Besançon

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Overview

Systematic review finds lower systolic BP may slow CKD progression, indicating careful BP management is necessary.

Key Points

  • Lower systolic BP levels, particularly ≤ 120 mmHg, are associated with slower GFR decline.
  • Studies indicate BP variability metrics predict faster CKD progression in several cohorts.
  • The review highlights the need for individualized BP targets based on patient characteristics.
  • Heterogeneity in methods and definitions limits the certainty of pooled outcomes from included studies.

Cite This Study

Smikadi et al. (2025) studied this question.

synapsesocial.com/papers/68ec51df42911f61ef8b2363https://doi.org/10.70779/aijshs.v4i10.363
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blood Pressure and Chronic Kidney Disease Progression: An Updated Review2022 · 30 citations
  2. 2Blood pressure targets in chronic kidney disease: still no consensus2023 · 7 citations
  3. 3Blood pressure targets for hypertension in people with chronic renal disease2024 · 6 citations
  4. 4Pros and cons of lower blood pressure targets in chronic kidney disease2025
  5. 5SPRINTing towards trials of blood pressure reduction to reduce CKD progression?2016 · 1 citations