Key result
Targeting SBP <120 mmHg reduces CV events and mortality in nondialysis CKD but increases AKI risk.
Why the study?
Recent updates in major international guidelines present differing recommendations for blood pressure targets in CKD, contributing to clinical uncertainty regarding the benefits and risks of lower targets.
Do lower systolic blood pressure targets (<120 mmHg) reduce cardiovascular events and mortality in patients with nondialysis chronic kidney disease?
Population
Patients with CKD
Comparison
Lower blood pressure targets vs standard targets
Design
Review
Authors
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Supports individualized lower SBP targets in nondialysis CKD despite AKI risk; leaves open optimal thresholds for dedicated RCTs.
Do lower systolic blood pressure targets (<120 mmHg) reduce cardiovascular events and mortality in patients with nondialysis chronic kidney disease?
Lower blood pressure targets (<120 mmHg) in nondialysis CKD provide cardiovascular benefits but require individualized approaches due to increased risks of AKI.
Hernandez et al. (2025) studied this question. Targeting lower systolic blood pressure (<120 mmHg) reduces cardiovascular events and all-cause mortality in nondialysis CKD but can increase AKI risk.
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