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March 3, 2019Current Opinion in Nephrology & HypertensionOpen Access

Lower target BP appears associated with lower mortality in CKD, although longer-term benefits with regard to kidney function remain unclear.

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Why the study?

Hypertension is common in chronic kidney disease (CKD), and the ideal systolic BP to reduce cardiovascular disease risk in individuals with CKD is controversial.

Does tighter blood pressure control reduce mortality and cardiovascular disease risk in individuals with chronic kidney disease?

Design

Review

Authors

BRBethany RoehmThe University of Texas Southwestern Medical CenterDWDaniel E. WeinerGeneral / Preventive / Lipids

Discussion

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Overview

May support lower BP targets to cut mortality in CKD; leaves open kidney outcomes and needs RCTs.

Structured PICO

Does tighter blood pressure control reduce mortality and cardiovascular disease risk in individuals with chronic kidney disease?

P
Population
Individuals with chronic kidney disease (CKD) and hypertension
I
Intervention
Intensive or tighter blood pressure control targets
C
Comparator
Standard blood pressure control targets
O
Outcome
Mortality, cardiovascular disease risk, and kidney outcomeshard clinical

Lower blood pressure targets in patients with CKD may reduce mortality, but treatment should be individualized due to unclear long-term kidney outcomes.

Cite This Study

Roehm et al. (2019) studied this question.

synapsesocial.com/papers/6a7e06fed491aa75eb151d02https://doi.org/10.1097/mnh.0000000000000492
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blood pressure targets in chronic kidney disease: still no consensus2023 · 7 citations
  2. 2Pros and cons of lower blood pressure targets in chronic kidney disease2025
  3. 3Blood pressure control in patients with chronic kidney disease2021 · 21 citations
  4. 4The role of blood pressure control in the prevention of cardiorenal disease in patients with chronic kidney disease2022 · 1 citations
  5. 5Hypertension in Chronic Kidney Disease (CKD): Diagnosis, Classification, and Therapeutic Targets2020 · 33 citations