November 29, 2022Nephrology Dialysis Transplantation

Guideline committees have come up with different recommendations for target BP despite the same body of evidence from clinical studies, complicating the question of optimal BP targets.

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Why the study?

Optimal blood pressure targets remain debated, with limited RCT data to determine optimal levels to prevent renal disease progression and conflicting guideline recommendations.

Does intensive blood pressure control with a goal of systolic BP <120 mmHg prevent cardiorenal disease in patients with chronic kidney disease compared to standard blood pressure control to a goal of systolic BP <140 mmHg?

Population

Patients with chronic kidney disease

Comparison

Intensive BP control (SBP <120 mmHg) vs standard BP control (SBP <140 mmHg)

Design

Review and opinion paper

Authors

GBGeorge Bonifant

Discussion

Member takes

Overview

Guideline discordance on BP targets in CKD cautions against uniform application; leaves open the need for consensus trials.

Structured PICO

Population

Patients with chronic kidney disease (CKD)

Intervention

Intensive blood pressure control with a goal of systolic BP <120 mmHg

Comparator

Standard blood pressure control to a goal of systolic BP <140 mmHg

Outcome

Prevention of cardiorenal disease (cardiovascular disease events and renal disease progression)

This review highlights the ongoing debate and lack of consensus among guidelines regarding optimal blood pressure targets for preventing cardiorenal events in patients with chronic kidney disease.

Limitations

Less data from RCTs for determining optimal BP levels to prevent renal disease progression
No studies in patients with CKD due to type 2 diabetes mellitus (T2DM) have been performed to investigate this problem

Cite This Study

George Bonifant (2022) studied this question.

synapsesocial.com/papers/6a7e4d36dea41f5fbab7b342 https://doi.org/10.1093/ndt/gfac313

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November 29, 2022Nephrology Dialysis Transplantation

Guideline committees have come up with different recommendations for target BP despite the same body of evidence from clinical studies, complicating the question of optimal BP targets.

View Full Paper

Ask AI

Bookmark

Why the study?

Optimal blood pressure targets remain debated, with limited RCT data to determine optimal levels to prevent renal disease progression and conflicting guideline recommendations.

Population

Patients with chronic kidney disease

Comparison

Intensive BP control (SBP <120 mmHg) vs standard BP control (SBP <140 mmHg)

Design

Review and opinion paper

Authors

GBGeorge Bonifant

Discussion

Member takes

Overview

Guideline discordance on BP targets in CKD cautions against uniform application; leaves open the need for consensus trials.

Structured PICO

Population

Patients with chronic kidney disease (CKD)

Intervention

Intensive blood pressure control with a goal of systolic BP <120 mmHg

Comparator

Standard blood pressure control to a goal of systolic BP <140 mmHg

Outcome

Prevention of cardiorenal disease (cardiovascular disease events and renal disease progression)

This review highlights the ongoing debate and lack of consensus among guidelines regarding optimal blood pressure targets for preventing cardiorenal events in patients with chronic kidney disease.

Limitations

Less data from RCTs for determining optimal BP levels to prevent renal disease progression
No studies in patients with CKD due to type 2 diabetes mellitus (T2DM) have been performed to investigate this problem

Cite This Study

George Bonifant (2022) studied this question.

synapsesocial.com/papers/6a7e4d36dea41f5fbab7b342 https://doi.org/10.1093/ndt/gfac313

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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