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October 15, 2025eLifeOpen Access

Age and learning shapes sound representations in auditory cortex during adolescence

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Authors

BPBenedikt PraegelHebrew University of JerusalemFCFeng ChenStanford UniversityADAdria DymEdmond and Lily Safra Children's Hospital

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Overview

Electrophysiological analysis reveals age-related changes in auditory discrimination in mice, indicating varying cognitive control with learning.

Key Points

  • Adolescent mice showed lower auditory discrimination performance on difficult tasks compared to adults, indicating developmental differences.
  • Using dense electrophysiological recordings, differences in auditory cortex activity were observed, particularly in response variability.
  • Cortical decoding in adolescents was found to be lower and slower, especially during challenging auditory tasks, reflecting immature neural representations.
  • Significant differences in cognitive control and behavioral profiles highlight the importance of ongoing development during adolescence.

Cite This Study

Praegel et al. (2025) studied this question.

synapsesocial.com/papers/68eff7392ae617e5891a9505https://doi.org/10.7554/elife.106387.4
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Also Consider

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