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October 16, 2025Open Access

In Vitro Antiproliferative Activity and Selective Cytotoxicity of Sixteen South African Euphorbia Species Against Breast Cancer and Normal Cell Lines

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Authors

IKIpeleng Kopano Rosinah Kgosiemang-XabaAAAyodeji Mathias AdegokeUniversity of IbadanSMSamson S. MasheleCentral University of Technology

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Implication

This investigation reveals selective cytotoxicity of Euphorbia species against breast cancer cells, suggesting medicinal potential.

Key Points

  • Certain Euphorbia species showed strong antiproliferative effects on breast cancer cell lines.
  • Euphorbia ledienii, cooperi, and clavarioides had CC₅₀ values of 0.06 μg/mL, 0.07 μg/mL, and 0.23 μg/mL, respectively.
  • A systematic method, including phytochemical screening and in vitro tests, highlighted the cytotoxic properties of the extracts.
  • These Euphorbia species exhibited selectivity for breast cancer cells while sparing normal cells, indicating potential therapeutic uses.

Cite This Study

Kgosiemang-Xaba et al. (2025) studied this question.

synapsesocial.com/papers/68f04935e559138a1a06e282https://doi.org/10.20944/preprints202510.0976.v1
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Also Consider

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