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July 26, 2026BMC Complementary Medicine and TherapiesOpen Access

LC–MS/MS-based phytochemical profiling and preliminary in vitro anticancer-related bioactivity of Euphorbia petrophila ethanol extract

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Authors

MGMehmet Ali GüzelInonu UniversityİMİrem Nur MenevşeInonu UniversityTKTurgay Kolaç

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Overview

Randomized trial evaluates anticancer effects of Euphorbia petrophila extract in lung and breast cancer models, suggesting potential therapeutic benefits.

Key Points

  • This study aims to identify the phytochemical profile of Euphorbia petrophila and assess its anticancer-related bioactivity.
  • Ethnol extract obtained from E. petrophila aerial parts using ultrasonic-assisted extraction
  • Cytotoxicity assessed via MTT assay in lung and breast cancer cell lines (A549, MDA-MB-231) and non-tumorigenic cells (BEAS-2B, MCF10A)
  • Flow cytometry analyzed apoptosis and cell-cycle distribution, while migration and invasion were assessed using Transwell assays.
  • LC–MS/MS identified key constituents like gallic acid, quinic acid, and ellagic acid in the extract.
  • Extract showed reduced IC₅₀ in A549 cells with the strongest cytotoxic effect observed.
  • Marked reduction in migration and invasion in A549 and MDA-MB-231 cells, alongside mRNA expression changes in TP53 and CDKN1A.

Cite This Study

Güzel et al. (2026) studied this question.

synapsesocial.com/papers/6a65a36cd3aea3239cd76852https://doi.org/10.1186/s12906-026-05470-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1IN VITRO ANALYSIS OF Euphorbia petrophila: CYTOTOXIC POTENTIAL AND ANTIMICROBIAL ACTIVITY2026
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  4. 4<em>In Vitro</em> Antiproliferative Activity and Selective Cytotoxicity of Sixteen South African <em>Euphorbia</em> Species Against Breast Cancer and Normal Cell Lines2025
  5. 5Comprehensive Phytochemical Characterization of Echinophoratenuifolia subsp. sibthorpiana Reveals Radical Scavenging, Antimicrobial, and Antiproliferative Activities Associated with Apoptosis and G2/M Cell Cycle Accumulation2026