What question did this study set out to answer?

To characterize the chemical profile and evaluate the antioxidant, antimicrobial, and antiproliferative activities of an acidified methanolic extract of Echinophora tenuifolia subsp. sibthorpiana.

August 20, 2026International Journal of Molecular SciencesOpen Access

Comprehensive Phytochemical Characterization of Echinophoratenuifolia subsp. sibthorpiana Reveals Radical Scavenging, Antimicrobial, and Antiproliferative Activities Associated with Apoptosis and G2/M Cell Cycle Accumulation

View Full Paper

Ask AI

Bookmark

Authors

UYUğur Yılmaz TKTurgay Kolaç MDMuhammed Dündar

Discussion

Member takes

Overview

In vitro analysis demonstrates antioxidant and apoptotic anticancer activity of Echinophora tenuifolia in human cancer cell lines, suggesting potential as a bioactive compound source.

Key Points

To characterize the chemical profile and evaluate the antioxidant, antimicrobial, and antiproliferative activities of an acidified methanolic extract of Echinophora tenuifolia subsp. sibthorpiana.
Characterized phenolic compounds, volatiles, and fatty acids using LC–MS/MS, GC–MS, and GC–FID, respectively.
Measured antioxidant capacity via DPPH and ABTS assays and evaluated antimicrobial activity using disc diffusion and broth microdilution.
Assessed antiproliferative activity across six human cancer cell lines and non-cancerous BEAS-2B cells, measuring apoptosis and cell-cycle progression via flow cytometry.
The extract showed a total phenolic content of 181.78 ± 5.03 mg GAE/g with DPPH and ABTS scavenging capacities of 333.65 ± 2.94 and 262.18 ± 6.80 mg TE/g, respectively.
Major identified compounds included methyl eugenol (51.10%) in volatile oil, lauric acid (29.71%) among fatty acids, and rutin hydrate and quinic acid among phenolics.
The extract demonstrated highest cytotoxicity in MCF-7 breast cancer cells (IC50 = 32.96 ± 4.80 μg/mL), inducing 57.93 ± 1.80% apoptosis and G2/M arrest, though selectivity compared to BEAS-2B control cells was limited.

Cite This Study

Yılmaz et al. (2026) studied this question.

synapsesocial.com/papers/6a86b5eb8a91293e6a1cd8a1 https://doi.org/10.3390/ijms27167385

View Full Paper

Ask AI

Bookmark

August 20, 2026International Journal of Molecular SciencesOpen Access

Comprehensive Phytochemical Characterization of Echinophoratenuifolia subsp. sibthorpiana Reveals Radical Scavenging, Antimicrobial, and Antiproliferative Activities Associated with Apoptosis and G2/M Cell Cycle Accumulation

View Full Paper

Ask AI

Bookmark

Authors

UYUğur Yılmaz TKTurgay Kolaç MDMuhammed Dündar

Discussion

Member takes

Overview

In vitro analysis demonstrates antioxidant and apoptotic anticancer activity of Echinophora tenuifolia in human cancer cell lines, suggesting potential as a bioactive compound source.

Key Points

To characterize the chemical profile and evaluate the antioxidant, antimicrobial, and antiproliferative activities of an acidified methanolic extract of Echinophora tenuifolia subsp. sibthorpiana.
Characterized phenolic compounds, volatiles, and fatty acids using LC–MS/MS, GC–MS, and GC–FID, respectively.
Measured antioxidant capacity via DPPH and ABTS assays and evaluated antimicrobial activity using disc diffusion and broth microdilution.
Assessed antiproliferative activity across six human cancer cell lines and non-cancerous BEAS-2B cells, measuring apoptosis and cell-cycle progression via flow cytometry.
The extract showed a total phenolic content of 181.78 ± 5.03 mg GAE/g with DPPH and ABTS scavenging capacities of 333.65 ± 2.94 and 262.18 ± 6.80 mg TE/g, respectively.
Major identified compounds included methyl eugenol (51.10%) in volatile oil, lauric acid (29.71%) among fatty acids, and rutin hydrate and quinic acid among phenolics.
The extract demonstrated highest cytotoxicity in MCF-7 breast cancer cells (IC50 = 32.96 ± 4.80 μg/mL), inducing 57.93 ± 1.80% apoptosis and G2/M arrest, though selectivity compared to BEAS-2B control cells was limited.

Cite This Study

Yılmaz et al. (2026) studied this question.

synapsesocial.com/papers/6a86b5eb8a91293e6a1cd8a1 https://doi.org/10.3390/ijms27167385

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark