What question did this study set out to answer?

To comprehensively characterize the non-volatile phytochemical constituents, antioxidant capacity, DNA-protective activity, and in vivo genotoxic safety profile of Echinophora sibthorpiana.

August 15, 2026AntioxidantsOpen Access

Phytochemical Analysis and Bioevaluation of Echinophora sibthorpiana Guss. (Apiaceae): Antioxidant Capacity, DNA Protection and In Vivo Genotoxic Safety

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Authors

SGSeren GündoğduHacettepe University GEGulnur Ipek ErdemliHacettepe University MBMerve Yüzbaşıoğlu BaranGülhane Askerî Tıp Akademisi

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Implication

In vitro and in vivo phytochemical evaluation demonstrates potent antioxidant and antigenotoxic properties of Echinophora sibthorpiana, highlighting its safety as a nutraceutical.

Key Points

To comprehensively characterize the non-volatile phytochemical constituents, antioxidant capacity, DNA-protective activity, and in vivo genotoxic safety profile of Echinophora sibthorpiana.
Fractionated aerial plant extracts using chromatographic methods and elucidated chemical structures using 1D/2D-NMR, HR-ESI-MS, and comparative LC-qTOF-MS across six Turkish species.
Evaluated antioxidant activity using CUPRAC, FRAP, and TEAC assays, and tested DNA-protective activity via the pBR322 plasmid model.
Assessed in vivo genotoxicity and antigenotoxicity against ethyl methanesulfonate using the Drosophila melanogaster wing somatic mutation and recombination test (SMART).
Isolated vicenin-2, rutin, isoquercitrin, and betulalbuside A from E. sibthorpiana for the first time, with the n-butanol fraction, rutin, and isoquercitrin demonstrating the strongest antioxidant and DNA-protective activities.
None of the isolated compounds or extracts exhibited genotoxic effects, whereas all samples displayed strong antigenotoxic activity against ethyl methanesulfonate-induced DNA damage, inhibiting total spot frequency by 47% to 83%.

Cite This Study

Gündoğdu et al. (2026) studied this question.

synapsesocial.com/papers/6a8019ce75c2e31742c85f3b https://doi.org/10.3390/antiox15081009

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Implication

In vitro and in vivo phytochemical evaluation demonstrates potent antioxidant and antigenotoxic properties of Echinophora sibthorpiana, highlighting its safety as a nutraceutical.

Phytochemical Analysis and Bioevaluation of Echinophora sibthorpiana Guss. (Apiaceae): Antioxidant Capacity, DNA Protection and In Vivo Genotoxic Safety

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Key Points

Cite This Study

Phytochemical Analysis and Bioevaluation of Echinophora sibthorpiana Guss. (Apiaceae): Antioxidant Capacity, DNA Protection and In Vivo Genotoxic Safety

Discussion

Member takes

Implication

Key Points

Cite This Study

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