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February 21, 2024Future Journal of Pharmaceutical SciencesOpen Access

Unveiling the anti-cancer potential of Euphorbia greenwayi: cytotoxicity, cell migration, and identification of its chemical constituents

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Authors

AZAhmed ZaghlolZKZeinab A. KandilMYMiriam F. Yousif

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Overview

In vitro screening demonstrates cytotoxicity and suppressed cell migration in cancer cell lines, suggesting therapeutic value for Euphorbia greenwayi metabolites.

Key Points

  • Nonpolar fractions of Euphorbia greenwayi show marked cytotoxicity against human cancer lines, while active phytochemicals halt breast cancer cell migration.
  • With IC50 values of 17.5 ± 0.6 and 18.6 ± 0.2 μg/ml, chloroform and hexane fractions suppress MCF-7 viability while yielding secondary metabolites.
  • Fractionation and cell migration assay on MCF-7 cultures isolate lupeol and cycloartenol—cell line model; further preclinical validation is required.

Cite This Study

Zaghlol et al. (2024) studied this question.

synapsesocial.com/papers/68e78341b6db6435876f65cehttps://doi.org/10.1186/s43094-024-00599-0
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  1. 1Phytochemical investigation of ethyl acetate extract from Curcuma aromatica Salisb. rhizomes2010 · 38 citations
  2. 2Evaluation of Immune Boosting Properties and Combating of Multiple Respiratory Viral Infections by fifteen Euphorbiaceae Plant Extracts2019 · 16 citations
  3. 3Cytotoxic Activity and Metabolic Profiling of Fifteen Euphorbia Species2020 · 45 citations