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October 15, 2025

Supplementary Figure 1 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma

Roy S Sayuri Miyauchi Riley N. Jones Sangwoo S. Kim Aldo Venuti A.S. Boparai Loren K. Mell Theresa Guo Joseph A. Califano Andrew B. Sharabi

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Key Points

HPV E5 expression is linked to increased resistance to chemotherapy in HNSCC cells, suggesting an adaptive survival mechanism.
In HNSCC cells, stem cell-like characteristics are enhanced by HPV E5, affecting their response to treatment.
The interaction of HPV E5 with HNSCC cells leads to changes in cellular phenotype, possibly contributing to therapeutic challenges.
Findings may inform future strategies to counteract HPV E5-mediated resistance in head and neck cancer therapies.

Implication

Observational analysis reveals HPV E5 promotes chemotherapy and radiation resistance in HNSCC, indicating a stem cell-like phenotype.

Abstract

Expression of HPV E5, E6 and E7 in different HNSCC cells and normal keratinocytes (HaCaT)

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Cite This Study

S et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcaf4 https://doi.org/10.1158/0008-5472.30363117

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 2 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma2025
2Supplementary Figure 5 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma2025
3Supplementary Figure 4 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma2025
4Data from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma2025
5HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell-Like Phenotype in Head and Neck Squamous Cell Carcinoma2025 · 3 citations