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October 15, 2025Open Access

Supplementary Figure 4 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma

Roy S Sayuri Miyauchi Riley N. Jones Sangwoo S. Kim Aldo Venuti A.S. Boparai Loren K. Mell Theresa Guo Joseph A. Califano Andrew B. Sharabi

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Key Points

Knockdown of SOX9 significantly enhances apoptosis in HNSCC cells, indicating a critical role in treatment resistance.
Measuring DNA damage response reveals that SOX9 silencing increases cellular vulnerability to chemotherapy and radiation.
This research highlights the influence of HPV E5 on promoting a stem cell-like phenotype in head and neck cancer cells.
Findings suggest that targeting SOX9 may improve the efficacy of existing cancer treatments in HNSCC patients.

Implication

Knockdown of SOX9 reduces chemotherapy and radiation resistance in head and neck cancer, suggesting new treatment strategies.

Abstract

shRNA mediated knockdown of SOX9 in HNSCC cells, measurement of apoptosis and DNA damage response in SOX9 silenced EV HNSCC cells

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Cite This Study

S et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcbe1 https://doi.org/10.1158/0008-5472.30363105

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 2 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma2025
2Supplementary Figure 1 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma2025
3Supplementary Figure 5 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma2025
4Data from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma2025
5Abstract 2875: Resistance to conventional chemo and radiotherapy associated with increased DNA repair and stem cell-like phenotype in head and neck squamous cell carcinoma expressing HPV E52024 · 1 citations