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October 15, 2025Open Access

Supplementary Figure 2 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma

Roy S Sayuri Miyauchi Riley N. Jones Sangwoo S. Kim Aldo Venuti A.S. Boparai Loren K. Mell Theresa Guo Joseph A. Califano Andrew B. Sharabi

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Key Points

Decreased E5 expression led to increased apoptosis in head and neck squamous cell carcinoma cells, enhancing treatment response.
Cells with E5 knockdown displayed altered DNA damage response, indicating impaired resistance mechanisms.
Assessment utilized apoptosis measurements and evaluated DNA response in HNSCC models with varying E5 expression.
Findings emphasize the potential for targeting HPV E5 to improve treatment outcomes in head and neck cancer patients.

Implication

Experimental knockdown of E5 decreased resistance to chemotherapy and radiation in HNSCC, suggesting a role in promoting stem cell-like traits.

Abstract

Measurement of apoptosis after knockdown of E5 in HNSCC cells and evaluation of DNA damage response in E5 expressed and E5 knockdown HNSCC cells

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Cite This Study

S et al. (2025) studied this question.

synapsesocial.com/papers/68f199c5de32064e504dcd92 https://doi.org/10.1158/0008-5472.30363114

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 1 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma2025
2Supplementary Figure 5 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma2025
3Supplementary Figure 4 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma2025
4Data from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma2025
5Abstract 2875: Resistance to conventional chemo and radiotherapy associated with increased DNA repair and stem cell-like phenotype in head and neck squamous cell carcinoma expressing HPV E52024 · 1 citations