Supplementary Figure 5 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma

Roy S; Sayuri Miyauchi; Riley Jones; Sangwoo S. Kim; Aldo Venuti; A.S. Boparai; Loren K. Mell; Theresa Guo; Joseph A. Califano; Andrew B. Sharabi

doi:10.1158/0008-5472.30363102

October 15, 2025Open Access

Supplementary Figure 5 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma

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Key Points

E5 expression levels correlate with chemotherapy and radiation resistance, affecting patient outcomes.
Patients with high E5 signature demonstrate poorer prognosis based on RNA-sequencing analysis.
E5 promotes a stem cell-like phenotype in HNSCC cells, which complicates treatment efficacy.
Single cell RNA-sequencing reveals distribution patterns of E5 in tumor samples, adding insight into therapy resistance.

Implication

Observational analysis shows E5 expression impacts prognosis in head and neck squamous cell carcinoma, indicating stem cell traits may enhance therapeutic resistance.

Abstract

Prognosis of HNSCC patients based on the status of E5 signature and expression distribution of E5 in single cell RNA-sequencing dataset

Discussion

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Cite This Study

S et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcc90 https://doi.org/10.1158/0008-5472.30363102

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Supplementary Figure 5 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 5 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma

Key Points

Implication

Abstract

Discussion

Cite This Study

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