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October 17, 2025World Journal of SurgeryOpen Access

Hilar Lymphadenectomy Is Associated With Improved Disease‐Free Survival in Pathologically N0 Non‐Small Cell Lung Cancer

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Authors

MCMarco ChiappettaCSCarolina SassorossiFLFilippo Lococo

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Overview

Retrospective analysis shows improved disease-free survival with lymphadenectomy in pathologically N0 non-small cell lung cancer patients, suggesting better guidelines are needed.

Key Points

  • Patients with N1 lymphadenectomy exhibited a higher disease-free survival rate of 76.3% compared to 57.8% in those with fewer than three N1 nodes resected.
  • The analysis included 487 patients, with a significant correlation found between higher resected N1 nodes and improved disease-free survival within 43 months of follow-up.
  • Kaplan–Meier curves and multivariable Cox-regression analysis were used to establish the link between lymphadenectomy parameters and disease-free survival outcomes.
  • Improved guidelines for lymphadenectomy are indicated based on the finding that more than three resected N1 nodes significantly correlates with better disease-free survival.

Cite This Study

Chiappetta et al. (2025) studied this question.

synapsesocial.com/papers/68f199c5de32064e504dd040https://doi.org/10.1002/wjs.70144
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