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May 22, 2026Journal of Clinical MedicineOpen Access

Rethinking pN1 Disease in Non-Small Cell Lung Cancer: Anatomical Subclassification, Surgical Extent, and Survival Outcomes

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Authors

EYEyüp Halit YardimciAAAleyna Gultekin AridasSASezer Aslan

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Overview

Retrospective study finds anatomical level of N1 metastasis impacts survival in NSCLC, indicating standard lobectomy suffices.

Key Points

  • To evaluate the impact of anatomical subclassification and surgical extent on survival outcomes in pN1 NSCLC.
  • Retrospective analysis of 150 patients with pN1 NSCLC undergoing curative-intent lung resection and nodal dissection.
  • Follow-up assessed from surgery until death or last follow-up until March 2026.
  • Analyzed clinicopathological variables including anatomical N1 level, nodal burden, and surgical extent.
  • Peripheral N1 involvement (stations 12–14) resulted in significantly longer survival than hilar/interlobar metastasis (stations 10–11) (p = 0.019).
  • Age (HR: 1.036, p = 0.026) and interlobar station 11 pN1 positivity (HR: 1.912, p = 0.044) were independent negative prognostic factors.
  • Extended resections did not improve survival and worsened outcomes in hilar/interlobar disease.

Cite This Study

Yardimci et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff3ffd674f7c03778cf6bhttps://doi.org/10.3390/jcm15103950
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