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July 6, 2026BMC Pulmonary MedicineOpen Access

Prognostic significance of nodal subclassification and adjuvant therapy in surgically treated T1-4N1-2M0 non-small cell lung cancer: a single-center retrospective study

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Authors

BEBekir ElmaAUAhmet UluşanMŞMaruf Şanlı

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Overview

Retrospective study evaluates prognostic factors in surgically treated lung cancer, suggesting refined subclassification can improve survival predictions.

Key Points

  • Evaluate the prognostic significance of nodal subclassification in T1-4N1-2M0 non-small cell lung cancer post-surgery.
  • Retrospective review of patients with pathologically confirmed T1-4N1-2M0 NSCLC who underwent anatomical lung resection.
  • Patients receiving preoperative therapy or with incomplete resections were excluded.
  • Nodal involvement categorized based on ninth Tumor-Node-Metastasis classification with survival analyzed using Kaplan-Meier and Cox regression.
  • Median overall survival was 45 months for N1, 30 months for N2a, and 19 months for N2b groups.
  • Younger age and adjuvant chemotherapy were linked to improved survival.
  • Multi-station and multi-zone metastases were associated with worse long-term outcomes.

Cite This Study

Elma et al. (2026) studied this question.

synapsesocial.com/papers/6a4b44fa997070ff83b5afbfhttps://doi.org/10.1186/s12890-026-04473-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic factors in resected non-small cell lung cancer with pathological N1 lymph node involvement: a survival analysis2026
  2. 2Prognostic impact of multiple N2 stations in patients with non small cell lung cancer2026
  3. 3Prognostic Factors in Resected Non-Small Cell Lung Cancer with Pathological N1 Lymph Node Involvement: A Survival Analysis2025
  4. 4Subgroup and prognostic factor analysis in T4 lung cancer based on the 9th Tumor-Node-Metastasis classification2025
  5. 5Rethinking pN1 Disease in Non-Small Cell Lung Cancer: Anatomical Subclassification, Surgical Extent, and Survival Outcomes2026