Circulating Tumor DNA as a Prognostic and Predictive Biomarker in Lung Cancer

Background/Objectives: Lung cancer remains a leading cause of cancer-related mortality worldwide. In recent years, the development of liquid biopsy, or ctDNA detection in body fluids, particularly blood, has been shown to be effective in detection, genotyping, prognostication, and evaluating therapy response, particularly in non-small cell lung cancer (NSCLC). Methods: In this review, we present a summary of the current landscape of ctDNA, applications, and limitations, as well as future areas of research. Results/Conclusions: Though not yet in its prime, ctDNA detection and tracking have powerful current and potential uses, including treatment selection, prognostication, and risk stratification.