Radical trifluoromethylation efficiently modifies heterocycles and aromatics, implying utility in pharmaceuticals.
Herein we report a simple radical aromatic trifluoromethylation process that utilizes a cationic, aromatic sulfonate ester as a trifluoromethyl radical photocage. This chemistry allows for the rapid and straightforward trifluoromethylation of diverse aromatics and heterocycles, including complex pharmaceuticals and natural products, with only substrate, photocage, solvent, and 456 nm light in minutes.
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Rustin et al. (2025) studied this question.
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