Photochemical Cu( iii )-mediated trifluoromethylation of (hetero)arenes and biomolecules

Petr Pospíšil; Vladimir Motornov; Ondřej Michal; Lucie Šálková; Sona Bohacova; tomáš Slanina; Jan Tarábek; Blanka Klepetářová; Petr Beier; Petr Pospíšil; Vladimir Motornov; Ondřej Michal; Lucie Wohlrábová; Sona Bohacova; tomáš Slanina; Jan Tarábek; Blanka Klepetářová; Petr Beier

doi:10.1039/d5sc07405c

Key Points

Trifluoromethylation enhances the properties of biomolecules, enabling potential advancements in drug design.
The method employs a substoichiometric amount of Cu(iii) complex, achieving efficient reactions.
Assessment indicates the approach is atom-economical, minimizing waste in the chemical process.
The findings suggest broader implications for the synthesis of complex organic molecules combining both biomolecules and heteroarenes.

Implication

Photochemical trifluoromethylation shows promising atom-economical results in biomolecules, indicating potential applications in organic synthesis.

Abstract

Atom-economical trifluoromethylation of (hetero)arenes, including selected biomolecules, was achieved using a substoichiometric amount of a Cu( iii ) trifluoromethyl complex.

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Cite This Study

Pospíšil et al. (2025) studied this question.

synapsesocial.com/papers/6925572cc0ce034ddc35a85e https://doi.org/10.1039/d5sc07405c

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Photochemical Cu( iii )-mediated trifluoromethylation of (hetero)arenes and biomolecules

Key Points

Implication

Abstract

Discussion

Cite This Study

Photochemical Cu( iii )-mediated trifluoromethylation of (hetero)arenes and biomolecules

Key Points

Implication

Abstract

Discussion

Cite This Study

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