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October 19, 2025GenesOpen Access

Stability Matters: Revealing Causal Roles of G-Quadruplexes (G4s) in Regulation of Chromatin and Transcription

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Authors

KXKe XiaoRZRongxin ZhangTTTiantong Tao

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Overview

This study reveals how g-quadruplex thermostability influences transcription factors, suggesting crucial genomic roles.

Key Points

  • G-quadruplex thermostability has causal effects on epigenetic states and transcription factor binding, impacting gene regulation.
  • Thermostability of transcription start site-proximal g-quadruplexes is linked to genes in proliferation and stress-response pathways.
  • A mapping strategy was developed to relate thermostability metrics and multi-omics signals with endogenous g-quadruplex regions.
  • Findings support that g-quadruplex structures play significant roles in chromatin organization and transcriptional control.

Cite This Study

Xiao et al. (2025) studied this question.

synapsesocial.com/papers/68f43ef4854d1061a58abc4chttps://doi.org/10.3390/genes16101231
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sequence Determinants of G-Quadruplex Thermostability: Aligning Evidence from High-Precision Biophysics and High-Throughput Genomics2025
  2. 2G‑quadruplexes as regulatory platforms for human transcription factors: insights from ChIP-seq data2026
  3. 3Function through shape: An overview of DNA G-quadruplexes in transcriptional regulation2026
  4. 4G-quadruplex structures as regulators of cellular processes and drivers of genome instability in cancer2026
  5. 5G4STAB: A multi-input deep learning model to predict G-quadruplex thermodynamic stability based on sequence and salt concentration.2025