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October 19, 2025Frontiers in PharmacologyOpen Access

Systematic review and network meta-analysis of the effects of bioactive compounds on pain intensity and quality of life in neuropathic pain patients

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Authors

RTRong TangCGChaoyang GongYLYuqian Liu

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Overview

Systematic review and network meta-analysis assess bioactive compounds' impact on pain and quality of life in neuropathic patients, suggesting promising interventions.

Key Points

  • Bioactive compounds effectively reduce pain intensity and improve quality of life in neuropathic pain patients.
  • The analysis included 20 randomized controlled trials with 2,471 patients, assessing various bioactive compounds.
  • Tetrahydrocannabinol was ranked as the most effective option for lowering pain intensity based on the Visual Analogue Scale.
  • Capsaicin was identified as the most promising intervention for improving anxiety and depression scores among patients.

Cite This Study

Tang et al. (2025) studied this question.

synapsesocial.com/papers/68f43f03854d1061a58ac3d0https://doi.org/10.3389/fphar.2025.1656400
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