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October 20, 2025Journal of Dental ResearchOpen Access

Multidimensional Artificial Intelligence–Based Cancer Progression Prediction in Oral Leukoplakia

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Authors

JAJohn AdeoyeChinese University of Hong KongHWHongqiu WangUniversity of Electronic Science and Technology of ChinaALAnthony W.I. LoQueen Mary Hospital

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Overview

This study develops an AI model for cancer progression prediction in oral leukoplakia, highlighting its effectiveness over current methods.

Key Points

  • OralCancerPredict achieved high concordance indices of 0.855 to 0.867 for cancer progression in oral leukoplakia.
  • The model's area under the curve was between 0.877 and 0.882, indicating strong predictive power.
  • External validation involved 119 patients and 322 tissue samples, ensuring model generalizability across varied data.
  • Compared to traditional risk stratification methods, OralCancerPredict offered a better net benefit for patient outcomes.

Cite This Study

Adeoye et al. (2025) studied this question.

synapsesocial.com/papers/68f58f68ece7a5b64f4715c2https://doi.org/10.1177/00220345251378053
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