The study reveals synthesis of unsymmetrical 7,7′-biindolizines through metal-free cycloaddition, suggesting novel functionalization possibilities.
Six new unsymmetrical 7,7′-biindolizines were synthesized through an efficient metal-free [2+2+1] cycloaddition of ethyl 3-benzoyl-7-(pyridin-4-yl)indolizine-1-carboxylate with two equivalents of dimethyl acetylenedicarboxylate in methanol. The transformation involves one C≡C triple bond cleavage and provides access to previously unexplored unsymmetrical functionalized 7,7′-biindolizines.
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Ciorteanu et al. (2025) studied this question.
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