Biomodeling Remote Consequences of Acute Phenylcarbamate Poisoning

Acute intoxications with pesticides, herbicides, and insecticides based on cholinesterase inhibitors account for up to 50% of hospitalizations due to toxic poisoning, leading to either long-term incapacitation or disability. These compounds predominantly cause dysfunction of the cholinergic mediator system, while exhibiting non-receptor effects. The consequences of severe carbamate poisoning can result in pathological conditions that occur in the long-term period of intoxication, including psycho-organic syndrome, asthenic conditions, neuropathies. The current literature lacks data on preventive or therapeutic drugs to prevent the occurrence of such conditions. The development of effective means of pharmacological correction requires adequate biomodels for studying remote effects of carbamate poisoning.