Observational analysis shows choline bitartrate reduces IL-6 and cholesterol levels in piglets, suggesting a hepatoprotective role.
Various methionine metabolites used in the treatment of experimental liver diseases in animals demonstrate hepatoprotective properties. The prophylactic use of choline was shown to provide intensive liver regeneration. In this study, we aim to evaluate the hepatoprotective effects of choline bitartrate in piglets, with an assessment of cytokine expression associated with the hepatobiliary system. The research was conducted using experimental pigs reared at the age of 45 days, which corresponds to the period of their early development. The use of choline bitartrate significantly reduces the expression of β transforming growth factor (TGF-β1) and pro-inflammatory interleukin 6 (IL-6) genes, at the same time as providing a significant reduction in total cholesterol and a proportional increase in HDL concentration, which is a classical anti-atherogenic factor.
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К.С. Остренко (2025) studied this question.
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