In vitro analysis reveals hypotensive effect of Xylaria polymorpha metabolites on the cardiovascular system, indicating enhanced endothelial function and reduced energy costs.
Xylaria polymorpha mushrooms produce a wide variety of secondary metabolites with unique chemical structures and diverse biological activities. The antimicrobial, antioxidant, and anti-inflammatory properties of Xylaria polymorpha metabolites were previously reported. The present study shows that an in vitro obtained extract obtained from the mycelial biomass of Xylaria polymorpha (Pers.) Grev. exhibits a hypotensive effect, due to an increase in the elastic properties of the main arteries (primarily the root and ascending aorta) and an improvement in endothelial function. This process is accompanied by a decrease in energy costs during cardiac contraction and an increase in the functional reserves of the cardiovascular system.
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Ravaeva et al. (2025) studied this question.
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