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October 23, 2025Blood AdvancesOpen Access

The Na/K-ATPase Alpha-1 Subunit Fine-Tunes Platelet P2Y12 Function and Mediates Sex-Dimorphism-Associated Thrombosis

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Authors

OLOliver Q LiYHYue HongADAutumn DeHart

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Overview

Investigation reveals haploinsufficiency reduces thrombosis in males but not females, indicating NKA's role in thrombotic risk.

Key Points

  • Haploinsufficiency of NKA alpha-1 significantly reduces thrombosis in male mice, highlighting sex-specific responses.
  • Platelet activation was measured through ADP-induced aggregation, revealing NKA alpha-1's crucial role.
  • Observational analysis of thrombosis models indicated unique responses in males based on NKA alpha-1 presence.
  • Research suggests NKA alpha-1 could serve as a biomarker and therapeutic target in thrombotic conditions.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68fa32a40df2e6cd2f74222chttps://doi.org/10.1182/bloodadvances.2025016605
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  4. 4Platelets of Female Mice Are Intrinsically More Sensitive to Agonists Than Are Platelets of Males2003 · 85 citations
  5. 5Impact of PI3Kα (Phosphoinositide 3-Kinase Alpha) Inhibition on Hemostasis and Thrombosis2018 · 30 citations