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February 6, 2013Blood

Angiotensin 1-7 and Mas decrease thrombosis in Bdkrb2−/− mice by increasing NO and prostacyclin to reduce platelet spreading and glycoprotein VI activation

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Population

Bradykinin B2 receptor-deleted mice (Bdkrb2-/-)

Comparison

Blockade of Mas with antagonist A-779, combined… vs Untreated Bdkrb2-/- mice or wild-type mice

Design

Preclinical

Authors

CFChao FangESEvi X. StavrouASAlec A. Schmaier

Discussion

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Overview

Mas antagonism accelerates thrombosis in Bdkrb2-/- mice; leaves open any role in human hemostasis.

Structured PICO

P
Population
Bradykinin B2 receptor-deleted mice (Bdkrb2-/-)
I
Intervention
Blockade of Mas with antagonist A-779, combined L-NAME and nimesulide treatment, or bone marrow transplantation
C
Comparator
Untreated Bdkrb2-/- mice or wild-type mice
O
Outcome
Carotid artery thrombosis times and tail bleeding timessurrogate

In Bdkrb2-/- mice, elevated Angiotensin 1-7 and Mas receptor activity delay thrombosis and prolong bleeding by increasing NO and prostacyclin, which can be reversed by Mas blockade.

Cite This Study

Fang et al. (2013) studied this question.

synapsesocial.com/papers/6a84f3ed57526c2f029de9cdhttps://doi.org/10.1182/blood-2012-09-459156
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin AT 2 Receptors Directly Stimulate Renal Nitric Oxide in Bradykinin B 2 -Receptor–Null Mice2003 · 155 citations
  2. 2Cyclooxygenase-2–Derived Prostacyclin Regulates Arterial Thrombus Formation by Suppressing Tissue Factor in a Sirtuin-1–Dependent-Manner2012 · 53 citations
  3. 3Coronary Kinin Generation Mediates Nitric Oxide Release After Angiotensin Receptor Stimulation1995 · 257 citations
  4. 4Mass spectrometry for the molecular imaging of angiotensin metabolism in kidney2012 · 65 citations
  5. 5The Antithrombotic Effect of Angiotensin-(1-7) Involves Mas-Mediated NO Release from Platelets2008 · 150 citations