Why the study?
Does Bradykinin B2 receptor knockout affect thrombosis risk and bleeding time in mice?
Does Bradykinin B2 receptor knockout affect thrombosis risk and bleeding time in mice?
Bradykinin B2 receptor knockout paradoxically protects against thrombosis by elevating nitric oxide and prostacyclin via increased angiotensin II binding to overexpressed AT2R.
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Animal data link BKB2R deletion to reduced thrombosis in mice; leaves open human relevance of AT2R-mediated effects.
Shariat‐Madar et al. (2006) studied this question.
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