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October 27, 2025European Journal of Preventive CardiologyOpen Access

Impact of weight/BMI on clinical and bleeding events in 26 805 atrial fibrillation patients on edoxaban from the Global ETNA-AF Registry

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Authors

GBGiuseppe BorianiPKPaulus KirchhofJSJosé Souza

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Overview

Analysis shows U-shaped relationships between body weight/BMI and stroke risk in atrial fibrillation patients, indicating targeted monitoring may be necessary.

Key Points

  • U-shaped relationships were observed between body mass index and all-cause death within two years.
  • Annualized rates of stroke and bleeding events increased significantly in patients weighing ≤60 kg.
  • Patients weighing between 60 and 80 kg had the lowest death rates in the study.
  • Clinicians should intensify monitoring for AF patients with low body weight or BMI thresholds.

Cite This Study

Boriani et al. (2025) studied this question.

synapsesocial.com/papers/68ff87d8c8c50a61f2bdca7dhttps://doi.org/10.1093/eurjpc/zwaf685
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of Weight on Clinical Outcomes of Edoxaban Therapy in Atrial Fibrillation Patients Included in the ETNA-AF-Europe Registry2021 · 12 citations
  2. 2Relationship between body mass index and outcomes in patients with atrial fibrillation treated with edoxaban or warfarin in the ENGAGE AF-TIMI 48 trial2018 · 135 citations
  3. 3Impact of body mass index on real-world outcomes of rivaroxaban treatment in Japanese patients with non-valvular atrial fibrillation2020 · 12 citations
  4. 4Clinical Outcomes in Patients With Atrial Fibrillation Treated With Non–Vitamin K Oral Anticoagulants Across Varying Body Mass Index2023 · 2 citations
  5. 5Association of body mass index with outcomes in patients with newly diagnosed atrial fibrillation: GARFIELD-AF2022 · 5 citations