History of Central Chemosensitivity Driving the Respiratory Rhythm Generator

This is the history on the hallmarks of central chemosensitivity during the period of 1958-1984 from Göttingen to Bochum and beyond. It deals with the primary literature on the axis of the signal reception by central chemoreceptors to the signal processing by medullary rhythm generator to target by the phrenic nerve activity and sympathetic drive to match breathing and circulation with the metabolic demand of the body. Additionally, it maintains the intactness of the brain acid-base homeostasis.