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November 21, 2025Chemistry & Biodiversity

Harnessing the Potential of Coffee Parchment as a Source of Bioactive Compounds to Modulate T Lymphocyte Proliferation, Activity, and Oxidative Stress

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Authors

AMAmel MEDJDOUBAIAsmahan ImessaoudeneACAhmed Chelihi

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Overview

In vitro evaluation reveals coffee parchment extract enhances lymphocyte activity and redox homeostasis, suggesting it as a source of nutraceuticals.

Key Points

  • This research aims to explore the effects of coffee parchment extract on T lymphocytes and oxidative stress.
  • Extract evaluated for effects on T lymphocyte proliferation and cytokine secretion.
  • T lymphocytes isolated using differential centrifugation and cultured with concanavalin A.
  • Cell viability assessed via MTT assay and cytotoxicity via micronucleus test.
  • Coffee parchment extract enhanced T lymphocyte proliferation and cytokine secretion (IL-2, IFN-γ).
  • At lower concentrations, it improved redox homeostasis and activated antioxidant defenses.
  • The extract's bioactive components, chlorogenic acid and caffeine, showed strong binding interactions with IFN-γ.

Cite This Study

MEDJDOUB et al. (2025) studied this question.

synapsesocial.com/papers/6924e3ecc0ce034ddc34eca4https://doi.org/10.1002/cbdv.202502274
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