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November 21, 2025Drug Development Research

Lysosome‐Mediated Targeted Protein Degradation: Emerging Chimeric Platforms for Extracellular and Intracellular Therapeutics

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Authors

SAShayan AsadiMTMina Taheri‐TorbatiPKPrashant Kesharwani

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Overview

This review uncovers mechanisms of chimeric platforms for protein degradation in precision medicine, suggesting new therapeutic avenues.

Key Points

  • The aim is to examine emerging chimeric platforms for protein degradation, particularly in therapeutic applications.
  • Review of proteolysis-targeting chimeras (PROTACs) and lysosome-targeting chimeras (LYTACs).
  • Evaluation of methylarginine-targeting chimeras (MrTACs) in lysosomal degradation.
  • Analysis of design strategies and bioanalytical challenges related to these platforms.
  • Highlighting the therapeutic implications of lysosome-mediated degradation.
  • Identifying potential applications in expanding druggable targets.
  • Illustrating a paradigm shift in targeted protein degradation (TPD).

Cite This Study

Asadi et al. (2025) studied this question.

synapsesocial.com/papers/6924e3ecc0ce034ddc34ee12https://doi.org/10.1002/ddr.70197
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lysosome‐Targeting Chimeras (LYTACs): From Modular Design Principles to Diverse Therapeutic Applications2026 · 1 citations
  2. 2Applications of Lysosome‐Targeting Receptors (LTRs) in Targeted Protein Degradation2025
  3. 3Unlocking the "undruggable": current landscape and emerging frontiers in lysosomal receptor-mediated protein degradation.2026 · 4 citations
  4. 4Polymeric Lysosomal-Targeting Chimeras: Extracellular Targeted Protein Degradation Without Co-opting Lysosome-Targeting Receptors2024 · 1 citations
  5. 5The application of drug delivery systems based on targeted protein degradation chimeras in disease treatment strategies2026 · 1 citations