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September 22, 2024

Polymeric Lysosomal-Targeting Chimeras: Extracellular Targeted Protein Degradation Without Co-opting Lysosome-Targeting Receptors

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Authors

RLRyan Hung-Hsun LuJKJithu KrishnaYAYasin Alp

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Cite This Study

Lu et al. (2024) studied this question.

synapsesocial.com/papers/68e57aefb6db64358751abf0https://doi.org/10.1101/2024.09.18.613672
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lysosome‐Mediated Targeted Protein Degradation: Emerging Chimeric Platforms for Extracellular and Intracellular Therapeutics2025
  2. 2Lysosome‐Targeting Chimeras (LYTACs): From Modular Design Principles to Diverse Therapeutic Applications2026 · 1 citations
  3. 3Expanding the Repertoireof Lysosomal Degradationof Membrane Proteins: A Generalizable Strategy Using Multivalent Antibody−PolymerChimeras2026
  4. 4Unlocking the "undruggable": current landscape and emerging frontiers in lysosomal receptor-mediated protein degradation.2026 · 4 citations
  5. 5Engineered Lysosome-Targeted Protein Degradation via Hijacking Macropinocytosis2026