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November 20, 2025JAMA Otolaryngology–Head & Neck Surgery

Peripheral Neural Plasticity in Cochlear Implant Users Across the Lifespan

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Authors

ELErik LarsenLLLeonid M. LitvakMLM Charles Liberman

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Overview

Cohort study shows cochlear implant improves auditory nerve function in users, suggesting critical early intervention is vital for long-term outcomes.

Key Points

  • To develop an automated method for analyzing auditory nerve function in cochlear implant users and to investigate changes across the lifespan.
  • Multicenter cohort study
  • Analysis of electrically evoked compound action potentials using nonlinear curve-fitting models
  • Data collected from clinical programming and follow-up across multiple US centers
  • Analysis involved 1,145,323 electrically evoked compound action potential recordings from 10,111 cochlear implants
  • Age at implantation significantly predicts nerve response slope, with younger recipients showing steeper slopes
  • Minimal slope changes seen in older recipients, indicating stabilization after age 30

Cite This Study

Larsen et al. (2025) studied this question.

synapsesocial.com/papers/6924f074c0ce034ddc34fb68https://doi.org/10.1001/jamaoto.2025.4050
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-Term Stability of Electrical Stimulation in Children with Bilateral Cochlear Implants2025
  2. 2Cochlear Nerve Responsiveness to Electrical Stimulation in Late-Implanted Prelingually Deafened Adults2026
  3. 3Age-Dependent Auditory Plasticity: Critical Periods in Subcortical and Cortical Encoding2026
  4. 4The effect of development on cortical auditory evoked potentials in normal hearing listeners and cochlear implant users2025 · 4 citations
  5. 5Of Kittens and Kids: Altered Cortical Maturation following Profound Deafness and Cochlear Implant Use2001 · 233 citations