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November 20, 2025Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsOpen Access

Subcellular Cartography of the Phosphoinositide Multiverse

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Authors

MRMorgan M C RicciCWClaire C. WeckerlyGHGerald R V Hammond

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Overview

Survey reveals phosphoinositides spatially regulate signaling in membranes, suggesting new directions in phosphoinositide biology.

Key Points

  • To investigate the distribution and role of phosphoinositides in eukaryotic cell membranes.
  • Historical and mechanistic analysis of phosphoinositide localization.
  • Surveys of live-cell biosensor studies.
  • Examination of kinase localization patterns.
  • Phosphoinositides play distinct roles in membrane identity and signaling.
  • PI(4,5)P₂ and PIP₃ are found at the plasma membrane.
  • PI4P and PI3P are located in the Golgi and endosomal systems.
  • PI(3,5)P₂ marks specialized late endosomal compartments.

Cite This Study

Ricci et al. (2025) studied this question.

synapsesocial.com/papers/6924f07fc0ce034ddc35005ehttps://doi.org/10.1016/j.bbalip.2025.159706
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Spatial organization of phosphoinositide signaling2025
  2. 2Abstract 1946 The long road paved by inositol phospholipids2024
  3. 3Abstract 2365 Class I phosphatidylinositol transfer proteins control organelle membrane lipid composition beyond supporting phosphoinositides synthesis2024
  4. 4Nuclear phosphoinositide signaling in cell biology and disease2026 · 5 citations
  5. 5Non-vesicular phosphatidylinositol transfer plays critical roles in defining organelle lipid composition2024 · 6 citations