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November 17, 2025FEBS Letters

Spatial organization of phosphoinositide signaling

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Authors

SLSiyu LaiWHWenbo HuangKHKangmin He

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Overview

This review shows phosphoinositide signaling regulates membrane trafficking and signal transduction, indicating roles in disease.

Key Points

  • The aim is to summarize current insights into the spatial organization of phosphoinositide signaling.
  • Review of the literature on phosphoinositide species and their spatial distribution
  • Discussion of the regulatory mechanisms involving lipid kinases and phosphatases
  • Highlighting roles of phosphoinositides in cellular processes and disease
  • Dysregulated phosphoinositide signaling is linked to various human diseases
  • Unique spatial distributions of phosphoinositides at subcellular levels enhance specific cellular functions
  • Phosphatases play a critical role in regulating the dynamics of phosphoinositides

Cite This Study

Lai et al. (2025) studied this question.

synapsesocial.com/papers/692509fbc0ce034ddc352ef1https://doi.org/10.1002/1873-3468.70227
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Subcellular Cartography of the Phosphoinositide Multiverse2025
  2. 2Approaches to visualize, quantify, and manipulate phosphoinositides in cells2026 · 2 citations
  3. 3Phosphoinositides at 50: From minor lipids to master organizers of polarity2025
  4. 4Nuclear phosphoinositide signaling in cell biology and disease2026 · 5 citations
  5. 5Phosphatidylinositol 3,4-bisphosphate: Out of the shadows and into the spotlight2024 · 5 citations