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November 20, 2025Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsOpen Access

Phosphoinositides at 50: From minor lipids to master organizers of polarity

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Authors

ADAma Gassama Diagne

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Overview

This review highlights the role of phosphoinositides in regulating polarity and cancer through cell signaling and lipid dynamics.

Key Points

  • The review aims to summarize the importance of phosphoinositides in cell polarity and tissue organization.
  • Comprehensive review of studies on phosphoinositides in various cell types including yeast, amoebae, and neutrophils.
  • Discussion on the role of phosphoinositides in apico-basal polarity and lumen morphogenesis.
  • Examination of interactions with Rho GTPases, polarity complexes, and septins.
  • Phosphoinositides are crucial for defining membrane identity and spatial cues in cells.
  • Alterations in phosphoinositide activity can lead to abnormal epithelial morphogenesis.
  • The review emphasizes the link between disrupted phosphoinositide function and the development of diseases like cancer.

Cite This Study

Ama Gassama Diagne (2025) studied this question.

synapsesocial.com/papers/6924f084c0ce034ddc3502c2https://doi.org/10.1016/j.bbalip.2025.159707
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Subcellular Cartography of the Phosphoinositide Multiverse2025
  2. 2Spatial organization of phosphoinositide signaling2025
  3. 3Nuclear phosphoinositide signaling in cell biology and disease2026 · 5 citations
  4. 4Abstract 1946 The long road paved by inositol phospholipids2024
  5. 5Regulation of yeast polarized exocytosis by phosphoinositide lipids2024