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November 20, 2025Brain SciencesOpen Access

Deep Brain Stimulation in Treatment-Resistant Psychiatric Disorders: Efficacy, Safety, and Future Directions

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Authors

MKMohsen Khosravi

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Overview

Review shows efficacy of Deep Brain Stimulation in reducing symptoms for disorders like OCD and PTSD, suggesting advances in treatment options.

Key Points

  • DBS demonstrates clinically meaningful symptom reductions, with response rates of 48% for depression and 35% for obsessive–compulsive disorder.
  • Safety profiles of DBS are generally acceptable; however, psychiatric adverse effects warrant careful patient monitoring.
  • Observational analysis reviews multiple treatment-resistant psychiatric disorders including bipolar disorder and Tourette’s syndrome.
  • Randomized controlled trials are lacking, indicating a need for rigorous studies and standard outcome measures.

Cite This Study

Mohsen Khosravi (2025) studied this question.

synapsesocial.com/papers/6924f07fc0ce034ddc35017bhttps://doi.org/10.3390/brainsci15111244
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deep Brain Stimulation for Refractory OCD and Depression: From Neurocircuitry to Personalised Neuromodulation.2026 · 1 citations
  2. 2Opportunities and challenges for the use of deep brain stimulation in the treatment of refractory major depression2024 · 1 citations
  3. 3Deep Brain Stimulation Is Beneficial for Treatment-Resistant Depression: A Systematic Review and Meta-Analysis of Clinical Trials and Long-Term Follow-Ups2025
  4. 4Deep brain stimulation beneficial for treatment-resistant depression: A systematic review and meta-analysis of clinical trials and long-term follow-up studies2026
  5. 5Deep Brain Stimulation: Past, Present, and Future2026