Deep brain stimulation beneficial for treatment-resistant depression: A systematic review and meta-analysis of clinical trials and long-term follow-up studies
Systematic review examines the effectiveness of deep brain stimulation in treatment-resistant depression, suggesting potential benefits over conventional methods.
Key Points
This review aims to evaluate the efficacy of deep brain stimulation in treating treatment-resistant depression compared to conventional therapies.
Performed systematic search in relevant databases and hand-searching of journals and grey literature.
Included controlled trials with at least one comparison group, such as sham.
Conducted random-effects meta-analysis and meta-regression analysis to assess treatment efficacy.
Meta-analysis included 11 studies with a Hedge's g of -0.51 favoring active stimulation over sham.
Long-term follow-up showed an effect size of g=-1.12 with a 56% response rate.
Population heterogeneity limited the potential for a universal DBS treatment approach.