What type of study is this?

This is a Systematic Review study (also classified as: Meta-Analysis).

October 1, 2025Open Access

Deep brain stimulation is beneficial for treatment-resistant depression: A systematic review and meta–analysis of clinical trials and long-term follow-ups

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Systematic review and meta-analysis identify deep brain stimulation's efficacy versus conventional treatments in treatment-resistant depression.

DBS provides greater efficacy for treatment-resistant depression compared to sham stimulation, with a medium-large effect size.
The meta-analysis revealed a standardized mean difference of -0.51 favoring active stimulation over sham in clinical trials.
Long-term follow-up showed a response rate of 56.14%, indicating effectiveness beyond immediate treatment.
Further large-scale studies are needed to substantiate the findings and confirm DBS's role in treating resistant depression.

Sepas et al. (2025) studied this question.

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October 1, 2025Open Access

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Authors

Systematic review and meta-analysis identify deep brain stimulation's efficacy versus conventional treatments in treatment-resistant depression.

DBS provides greater efficacy for treatment-resistant depression compared to sham stimulation, with a medium-large effect size.
The meta-analysis revealed a standardized mean difference of -0.51 favoring active stimulation over sham in clinical trials.
Long-term follow-up showed a response rate of 56.14%, indicating effectiveness beyond immediate treatment.
Further large-scale studies are needed to substantiate the findings and confirm DBS's role in treating resistant depression.

Sepas et al. (2025) studied this question.

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