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September 5, 2025Open Access

Deep brain stimulation for major depressive disorder: A Systematic Review and Meta-Analysis

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Authors

BDBenjamin DavidsonFMFelicia ManocchioMPMartin Profant

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Overview

Systematic review and meta-analysis reveal sustained antidepressant effects of DBS in treatment-resistant depression.

Key Points

  • Symptoms improved significantly following deep brain stimulation, indicating its potential in treatment-resistant depression.
  • Effect sizes for DBS were notable at 2.40 for short-term, 2.83 for moderate-term, and 4.33 for long-term assessments.
  • The analysis incorporated both open-label and randomized controlled trials to evaluate the impact of DBS on depressive symptoms.
  • Further investigation may optimize clinical implementation and clarify efficacy against placebo for DBS.

Cite This Study

Davidson et al. (2025) studied this question.

synapsesocial.com/papers/68bb3a492b87ece8dc95586dhttps://doi.org/10.21203/rs.3.rs-7238063/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deep Brain Stimulation Is Beneficial for Treatment-Resistant Depression: A Systematic Review and Meta-Analysis of Clinical Trials and Long-Term Follow-Ups2025
  2. 2Deep brain stimulation is beneficial for treatment-resistant depression: A systematic review and meta–analysis of clinical trials and long-term follow-ups2025
  3. 3Deep brain stimulation beneficial for treatment-resistant depression: A systematic review and meta-analysis of clinical trials and long-term follow-up studies2026
  4. 4Deep brain stimulation for treatment-resistant major depressive disorder: a network meta-analysis of stimulation targets2025 · 1 citations
  5. 5Deep Brain Stimulation for Refractory OCD and Depression: From Neurocircuitry to Personalised Neuromodulation.2026 · 1 citations