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September 17, 2025Open Access

Deep Brain Stimulation Is Beneficial for Treatment-Resistant Depression: A Systematic Review and Meta-Analysis of Clinical Trials and Long-Term Follow-Ups

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Authors

ASAli SepasAalborg UniversityHAHussein AlkafajiAalborg UniversityVAVedat AticiAalborg University

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Implication

Meta-analysis reveals deep brain stimulation improves outcomes for patients with treatment-resistant depression, suggesting innovative therapeutic options.

Key Points

  • Meta-analysis shows deep brain stimulation significantly improves outcomes for treatment-resistant depression compared to sham.
  • The effect size favoring active stimulation is medium-large, with Hedge's g reported at -0.51 in included studies.
  • A systematic review of 14 clinical trials indicates a pooled response rate of 56.14% after long-term follow-up with DBS.
  • These findings highlight the necessity for further robust studies to validate the effectiveness of DBS in treatment-resistant depression.

Cite This Study

Sepas et al. (2025) studied this question.

synapsesocial.com/papers/68d45e6a31b076d99fa5f1b7https://doi.org/10.32388/47tw5n
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Also Consider

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  4. 4The Hamilton Depression Rating Scale: Has the Gold Standard Become a Lead Weight?2004 · 1,160 citations
  5. 5Response of Depression to Electroconvulsive Therapy2015 · 316 citations