What question did this study set out to answer?

To investigate prognostic factors for survival after upfront surgery in patients with resectable pancreatic ductal adenocarcinoma and develop a prediction model.

November 18, 2025CancersOpen Access

Prognosis Prediction Model After Upfront Surgery for Resectable Pancreatic Ductal Adenocarcinoma: A Multicenter Study (OS-HBP-2)

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Authors

KTKosei Takagi RYRyuichi Yoshida KYKazuya Yasui

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Implication

Multicenter study identifies prognostic factors impacting survival in patients post-upfront surgery for pancreatic ductal adenocarcinoma, suggesting a new prediction model.

Key Points

To investigate prognostic factors for survival after upfront surgery in patients with resectable pancreatic ductal adenocarcinoma and develop a prediction model.
Multicenter, retrospective study including 603 patients undergoing upfront surgery for resectable PDAC.
Performed univariate and multivariate analyses to identify prognostic factors for overall survival.
Constructed a prognostic prediction model for overall survival after initial surgery with internal validation.
1-year overall survival rate of 83.7%, 3-year rate of 48.2%, and 5-year rate of 37.5%.
Identified predictors of overall survival included tumor size, carbohydrate antigen 19-9 levels, and modified Glasgow Prognostic Score.
The developed prediction model demonstrated a concordance index of 0.63.

Cite This Study

Takagi et al. (2025) studied this question.

synapsesocial.com/papers/6924feebc0ce034ddc351ae3 https://doi.org/10.3390/cancers17223694

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Implication

Multicenter study identifies prognostic factors impacting survival in patients post-upfront surgery for pancreatic ductal adenocarcinoma, suggesting a new prediction model.

Prognosis Prediction Model After Upfront Surgery for Resectable Pancreatic Ductal Adenocarcinoma: A Multicenter Study (OS-HBP-2)

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Implication

Key Points

Cite This Study

Prognosis Prediction Model After Upfront Surgery for Resectable Pancreatic Ductal Adenocarcinoma: A Multicenter Study (OS-HBP-2)

Discussion

Member takes

Implication

Key Points

Cite This Study

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