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November 18, 2025Scientific ReportsOpen Access

Ability of the hypotension prediction index to predict hypotension in patients with septic shock in the intensive care unit

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Authors

BKBodin KhwannimitNSNatthaka SathapornVVVeerapong Vattanavanit

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Overview

Prospective study finds septic shock patients' hypotension predicted by MAP, indicating room for HPI improvement.

Key Points

  • Evaluate the hypotension prediction index for predicting hypotension in ICU patients with septic shock.
  • Prospective study design
  • Data collected from 30 patients with septic shock
  • Hypotension defined as mean arterial pressure < 65 mmHg for ≥ 1 min
  • Analyzed 293,315 data points with 645 hypotensive events
  • HPI showed excellent performance predicting hypotension at 5 and 10 minutes before events
  • AUC at 5 min was 0.953, better than at 15 min (0.919)
  • When including MAP 65-75 mmHg as non-hypotension, HPI's predictive ability declined
  • AUC for MAP was similar to HPI at all time points when considering 65-75 mmHg

Cite This Study

Khwannimit et al. (2025) studied this question.

synapsesocial.com/papers/6924feebc0ce034ddc351b2ahttps://doi.org/10.1038/s41598-025-24270-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ability of the hypotension prediction index to predict hypotension in patients with septic shock in the intensive care unit2025 · 3 citations
  2. 2Validation and clinical applicability of the Hypotension Prediction Index in a general ICU population: a prospective observational cohort study Study acronym Prediction of Hemodynamic Instability in Patients Admitted to the ICU; the PHYSIC study2024
  3. 3Performance of the hypotension prediction index as an indicator of hypotensive haemodynamic instability in surgical patients2026
  4. 4Performance of a Machine Learning Algorithm to Predict Hypotension in Spontaneously Breathing Non-Ventilated Post-Anesthesia and ICU Patients2024 · 1 citations
  5. 5Hypotension prediction index in surgical patients: A systematic review and meta-analysis of randomized controlled trials2026 · 1 citations